Publications

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2023
Complex Behavior
Early Life Stress
Gene X Stress Interaction: Epigenetic Mechanisms
Metabolism and Eating Disorders
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Yair Shemesh, Chen A
A paradigm shift in translational psychiatry through rodent neuroethology. Mol Psychiatry. 2023 Jan 12. doi: 10.1038/s41380-022-01913-z.
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2022
Stress Circuitry and Regulation
Chenani A, Weston G, Ulivi AF, Castello-Waldow TP, Huettl RE, Chen A, Attardo A.
Repeated stress exposure leads to structural synaptic instability prior to disorganization of hippocampal coding and impairments in learning. Transl Psychiatry, 12(1):381. doi: 10.1038/s41398-022-02107-5.
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Stress Circuitry and Regulation
Ruat J, Genewsky AJ, Heinz DE, Kaltwasser SF, Canteras NS, Czisch M, Chen A, Wotjak CT
Why do mice squeak? Toward a better understanding of defensive vocalization. iScience, 25(7):104657. doi: 10.1016/j.isci.2022.104657.
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Complex Behavior
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R, Flachskamm C, Ressle A, Roeh S, Huettl RE, Parl A, Eggert C, Novak B, Yan Y, Yeoh K, Holzapfel M, Hauger B, Harbich D, Schmid B, Di Giaimo R, Turck CW, Schmidt MV, Deussing JM, Eder M, Dine J, Theis FJ, Chen A.
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron, doi: 10.1016/j.neuron.2022.05.001.
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Stress Linked Psychopathologies
Amitai M, Kaffman S, Kroizer E, Lebow M, Magen I, Benaroya-Milshtein N, Fennig S, Weizman A, Apter A, Chen A.
Neutrophil to-lymphocyte and platelet-to-lymphocyte ratios as biomarkers for suicidal behavior in children and adolescents with depression or anxiety treated with selective serotonin reuptake inhibitors. Brain Behav. Immun.. doi: 10.1016/j.bbi.2022.04.018.
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2021
Stress Circuitry and Regulation
Ruat J, Hartmann A, Heinz DE, Nemcova P, Stoffel R, Deussing JM, Chen A, Wotjak CT.
CB1 receptors in corticotropin-releasing factor neurons selectively control the acoustic startle response in male mice. Genes Brain Behav., 2021;e12775. doi: 10.1111/gbb.12775.
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Stress Circuitry and Regulation
Furman O, Tsoory M, Chen A.
Differential chronic social stress models in male and female mice. Eur J Neurosci. doi: 10.1111/ejn.15481
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Stress Linked Psychopathologies
Benjamin A, Kuperman Y, Eren N, Rotkopf R, Amitai M, Rossman H, Shilo S, Meir T, Keshet A, Nuttman-Shwartz O, Segal E, Chen A.
Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak. Mol Psychiatry. doi: 10.1038/s41380-021-01219-6.
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Stress Circuitry and Regulation
Ruat J, Heinz DE, Binder FP, Stark T, Neuner R, Hartmann A, Kaplick PM, Chen A, Czisch M, Wotjak CT.
Structural correlates of trauma-induced hyperarousal in mice. Prog Neuropsychopharmacol Biol Psychiatry. 111:110404. doi: 10.1016/j.pnpbp.2021.110404.
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Gene X Stress Interaction: Epigenetic Mechanisms
Stress Circuitry and Regulation
Dick ALW, Chen A.
The role of TET proteins in stress-induced neuroepigenetic and behavioural adaptations. Neurobiol Stress 15:100352. doi: 10.1016/j.ynstr.2021.100352. eCollection 2021 Nov.
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Stress Linked Psychopathologies
Mevorach T, Taler M, Dar S, Lebow M, Schorr Sapir I, Rotkopf R, Apter A, Fennig S, Chen A, Weizman A, Amitai M.
The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents. Sci Rep 11, Article number: 11798. doi: 10.1038/s41598-021-90971-4.
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Stress Linked Psychopathologies
Bortolozzi A, Manashirov S, Chen A, Artigas F.
Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson's disease. Pharmacol Ther. 2021 Apr 26;107873. doi: 10.1016/j.pharmthera.2021.107873.
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Stress Circuitry and Regulation
Lee CR, Chen A, Tye KM.
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. Cell, 184 (6): 1500-1516. doi: 10.1016/j.cell.2021.02.028.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Lopez JP, Brivio E, Santambrogio A, De Donno C, Kos A, Peters M, Rost N, Czamara D, Brückl TM, Roeh S, Pöhlmann ML, Engelhardt C, Ressle A, Stoffel R, Tontsch A, Villamizar JM, Reincke M, Riester A, Sbiera S, Fassnacht M, Mayberg HS, Craighead WE, Dunlop BW, Nemeroff CB, Schmidt MV, Binder EB, Theis FJ, Beuschlein F, Andoniadou CL, Chen A.
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation. Science Advances, vol. 7, no. 5, eabe4497.
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2020
Gene X Stress Interaction: Epigenetic Mechanisms
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Fiori LM, Kos A, Lin R, Théroux JF, Lopez JP, Kühne C, Eggert C, Holzapfel M, Hüttl RE, Mechawar N, Belzung C, Ibrahim EC, Chen A, Turecki G.
miR-323a regulates ERBB4 and is involved in depression. Mol Psychiatry. doi: 10.1038/s41380-020-00953-7.
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Stress Linked Psychopathologies
Amitai M, Taler M, Lebow M, Ben-Baruch R, Apter A, Fennig S, Weizman A, Chen A
An increase in IL-6 levels at 6-month follow-up visit is associated with SSRI-emergent suicidality in high-risk children and adolescents treated with fluoxetine. Eur Neuropsychopharmacol, 40, 61-69. doi: 10.1016/j.euroneuro.2020.07.007
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Complex Behavior
Stress Circuitry and Regulation
Karamihalev S, Brivio E, Flachskamm F, Stoffel R, Schmidt MV, Chen A.
Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner. eLife, 9:e58723. doi: 10.7554/eLife.58723.
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Complex Behavior
Anpilov S, Shemesh Y, Eren N, Harony-Nicolas H, Benjamin A, Dine J, Oliveira VEM, Forkosh O, Karamihalev K, Hüttl RE, Feldman N, Berger R, Dagan A, Chen G, Neumann ID, Wagner S, Yizhar O, Chen A.
Wireless optogenetic stimulation of oxytocin neurons in a semi-natural setup dynamically elevates both pro-social and agonistic behaviors. Neuron. doi: 10.1016/j.neuron.2020.05.028.
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Gene X Stress Interaction: Epigenetic Mechanisms
Brivio E, Lopez JP, Chen A.
Sex differences: Transcriptional signatures of stress exposure in male and female brains. Genes Brain Behav., e12643. doi: 10.1111/gbb.12643.
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2019
Stress Linked Psychopathologies
Amitai M, Taler M, Ben-Baruch R, Lebow M, Rotkopf R, Apter A, Fennig S, Weizman A, Chen A.
Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth. Brain Behav Immun., pii: S0889-1591(19)31330-3.
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Stress Circuitry and Regulation
Lerner S, Anderzhanova E, Verbitsky S, Eilam R, Kuperman Y, Tsoory M, Kuznetsov Y, Brandis A, Mehlman T, Mazkereth R, UCDC Neuropsychologists, McCarter R, Segal M, Nagamani SCS, Chen A, Erez A.
ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus. Cell Rep., 29 (8): 2144-2153.
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Complex Behavior
Forkosh O, Karamihalev S, Röh S, Alon U, Anpilov S, Touma C, Nussbaumer M, Flachskamm C, Kaplick PM, Shemesh Y, Chen A.
Identity domains capture individual differences from across the behavioral repertoire. Nat Neurosci., 22 (12): 2023-2028.
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Complex Behavior
Stress Circuitry and Regulation
Karamihalev S, Flachskamm C, Eren N, Kimura M, Chen A.
Social context and dominance status contribute to sleep patterns and quality in groups of freely-moving mice. Sci. Rep. 9, Article number: 15190.
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Early Life Stress
Gene X Stress Interaction: Epigenetic Mechanisms
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Edited by Alon Chen.
Stress Resilience: Molecular and Behavioral Aspects. Elsevier Academic Press. DOI: 10.1016/C2016-0-03233-3.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Lebow MA, Schroeder M, Tsoory M, Holzman-Karniel D, Mehta D, Ben-Dor S, Gil S, Bradley B, Smith AK, Jovanovic T, Ressler KJ, Binder EB, Chen A.
Glucocorticoid-induced leucine zipper “quantifies” stressors and increases male susceptibility to PTSD. Transl. Psychiatry, volume 9, Article number: 178.
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Gene X Stress Interaction: Epigenetic Mechanisms
Stress Circuitry and Regulation
Dick ALW, Khermesh K, Paul E, Stamp F, Levanon EY, Chen A.
Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain Regions Is Regulated in Response to Chronic Social Defeat Stress in Mice. Front. Psychiatry 10:277. doi: 10.3389/fpsyt.2019.00277.
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2018
Early Life Stress
Gene X Stress Interaction: Epigenetic Mechanisms
Metabolism and Eating Disorders
Stress Linked Psychopathologies
Schroeder M, Jakovcevski M, Polacheck T, Drori Y, Ben-Dor S, Röh S, Chen A.
Sex dependent impact of gestational stress on predisposition to eating disorders and metabolic disease. Mol Metab. pii: S2212-8778(18)30624-0.
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Stress Circuitry and Regulation
Deussing JM and Chen A.
The Corticotropin-Releasing Factor Family: Physiology of the Stress Response. Physiol Rev. 98(4):2225-2286.
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Gene X Stress Interaction: Epigenetic Mechanisms
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Engel M, Eggert C, Kaplick PM, Eder M, Roeh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, Jakovcevski M, Hanna JH, Leshkowitz D, Uhr M, Wotjak CT, Schmidt MV, Deussing JM, Binder EB, Chen A.
The Role of m6A/m-RNA Methylation in Stress Response Regulation. Neuron. 99(2):389-403.e9.
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Stress Circuitry and Regulation
Ezra-Nevo G, Prestori F, Locatelli F, Soda T, ten Brinke M, Engel M, Boele H, Botta L, Leshkowitz D, Ramot A, Tsoory M, Biton I, Deussing J, D'Angelo E, De Zeeuw C, Chen A.
Cerebellar learning properties are modulated by the CRF receptor in granular cells. J Neurosci. 3106-15.
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Stress Circuitry and Regulation
Ezra-Nevo G, Volk N, Ramot A, Kühne C, Tsoory M, Deussing JM, Chen A.
Inferior olive CRF plays a role in motor performance under challenging conditions. Transl. Psychiatry. 8:107.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM.
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 21(6):803-807.
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Early Life Stress
Gene X Stress Interaction: Epigenetic Mechanisms
Metabolism and Eating Disorders
Stress Linked Psychopathologies
Schroeder M, Jakovcevski M, Polacheck T, Drori Y, Luoni A, Röh S, Zaugg J, Ben-Dor S, Albrecht C, Chen A.
Placental miR-340 mediates vulnerability to activity based anorexia in mice. Nat Commun. 9(1):1596.
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Gene X Stress Interaction: Epigenetic Mechanisms
Metabolism and Eating Disorders
Pardo M, Kuperman Y, Levin L, Rudich A, Haim Y, Schauer JJ, Chen A, Rudich Y.
Exposure to air pollution interacts with obesogenic nutrition to induce tissue-specific response patterns. Environ Pollut. 239:532-543.
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Gene X Stress Interaction: Epigenetic Mechanisms
Metabolism and Eating Disorders
Schroeder M, Drori Y, Ben-Efraim YJ, Chen A.
Hypothalamic miR-219 regulates individual metabolic differences in response to diet-induced weight cycling. Mol Metab. 9:176-186.
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2017
Metabolism and Eating Disorders
Stress Circuitry and Regulation
Balsevich G, Häusl AS, Meyer CW, Karamihalev S, Feng X, Pöhlmann ML, Dournes C, Uribe-Marino A, Santarelli S, Labermaier C, Hafner K, Mao T, Breitsamer M, Theodoropoulou M, Namendorf C, Uhr M, Paez-Pereda M, Winter G, Hausch F, Chen A, Tschöp MH, Rein T, Gassen NC, Schmidt MV.
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. Nat Commun. 8(1):1725.
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Gene X Stress Interaction: Epigenetic Mechanisms
Stress Linked Psychopathologies
Engel M and Chen A.
The emerging role of mRNA methylation in normal and pathological behavior. Genes Brain Behav. 2017;e12428.
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Early Life Stress
Gene X Stress Interaction: Epigenetic Mechanisms
Metabolism and Eating Disorders
Stress Linked Psychopathologies
Schroeder M, Jakovcevski M, Polacheck T, Lebow M, Drori Y, Engel M, Ben-Dor S, Chen A.
A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype. Cell Metab. 25:1269-1281.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Dedic N, Chen A, Deussing JM.
The CRF family of neuropeptides and their receptors - mediators of the central stress response. Curr Mol Pharmacol. 11(1):4-31.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Ramot A, Jiang Z, Tian JB, Nahum T, Kuperman Y, Justice NJ, Chen A.
Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nat Neurosci. 20:385-388.
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2016
Gene X Stress Interaction: Epigenetic Mechanisms
Stress Linked Psychopathologies
Volk N, Pape JC, Engel M, Zannas AS, Cattane N, Cattaneo A, Binder EB, Chen A.
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. Cell Rep. 17:1882-1891.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Henckens MJAG, Deussing JM, Chen A.
Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat Rev Neurosci. 17:636-651.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Henckens MJAG, Printz Y, Shamgar U, Lebow M, Drori Y, Kuehne C, Kolarz A, Deussing JM, Justice NJ, Yizhar O, Chen A.
The posterior bed nucleus of the stria terminalis critically contributes to stress recovery. Mol. Psychiatry 22:1691–1700.
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Complex Behavior
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Eliott E, Tabouy L, Ezra G, Adler ES, Ben-Efraim Y, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing JM, Schneidman E, Yizhar O, Chen A.
Ucn3–CRFR2 in the medial amygdala regulates complex social dynamics. Nat Neurosci. 19:1489-1496.
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Metabolism and Eating Disorders
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Kuperman Y, Weiss M, Dine J, Staikin K, Golani O, Ramot A, Nahum T, Kühne C, Shemesh Y, Wurst W, Harmelin A, Deussing JM, Eder M and Chen A.
CRFR1 in AgRP neurons modulates sympathetic nervous system activity to adapt to cold stress and fasting. Cell Metab. 23:1185-1199.
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Lebow M and Chen A.
Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders. Mol. Psychiatry 21:450-463.
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Gene X Stress Interaction: Epigenetic Mechanisms
Stress Linked Psychopathologies
Elliott E, Manashirov S, Zwang R, Gil S, Tsoory M, Shemesh Y, Chen A.
Dnmt3a in the medial prefrontal cortex regulates anxiety-like behavior in adult mice. J Neurosci. 36:730-740.
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2015
Gene X Stress Interaction: Epigenetic Mechanisms
Stress Linked Psychopathologies
Issler O and Chen A.
Determining the role of microRNAs in psychiatric disorders. Nat Rev Neurosci. 16:201-212. [20]
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2014
Gene X Stress Interaction: Epigenetic Mechanisms
Stress Linked Psychopathologies
Volk N, Paul ED, Haramati S, Eitan C, Fields BK, Zwang R, Gil S, Lowry CA, Chen A.
MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1. J Neurosci. 34:15070-15082. [10]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Chen NA, Jupp B, Sztainberg Y, Lebow M, Brown RM, Kim JH, Chen A, Lawrence AJ.
Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice. J Neurosci. 34:11560-11570. [5]
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Gene X Stress Interaction: Epigenetic Mechanisms
Stress Linked Psychopathologies
Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A.
MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron 83:344-360. [75]
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2013
Complex Behavior
Shemesh Y, Sztainberg Y, Forkosh O, Shlapobersky T, Chen A, Schneidman E.
High-order social interactions in groups of mice. eLife 2:e00759. [19]
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Metabolism and Eating Disorders
Stress Circuitry and Regulation
Greenman Y, Kuperman Y, Drori Y, Asa SL, Navon I, Forkosh O, Gil S, Stern N, Chen A.
Postnatal Ablation of POMC Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior. Mol Endocrinol. 27:1091-1102. [19]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Lucas M, Chen A, Richter-Levin G.
Hypothalamic corticotropin-releasing factor is centrally involved in learning under moderate stress. Neuropsychopharmacology 38:1825-1832.
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2012
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Neufeld-Cohen A, Kelly PA, Paul ED, Carter RN, Skinner E, Olverman HJ, Vaughan JM, Issler O, Kuperman Y, Lowry CA, Vale WW, Seckl JR, Chen A, Jamieson PM.
Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge. Biol Psychiatry 72:437-447. [17]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Bale TL, Chen A.
Minireview: CRF and Wylie Vale: A Story of 41 Amino Acids and a Texan with Grit. Endocrinology 153:2556-2561. [11]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Lebow M, Neufeld-Cohen A, Kuperman Y, Gil S and Chen A.
Susceptibility to PTSD is mediated by CRF receptor type 2 levels in the bed nucleus of the stria terminalis. J Neurosci. 32:6906-6916. [33]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Regev R, Tsoory M, Gil S, Chen A.
Site-specific genetic manipulation of amygdala CRF reveals its imperative role in mediating behavioral response to challenge. Biol Psychiatry 71:317-326. [41]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Amir-Zilberstein L, Blechman J, Sztainberg Y, Norton WHJ, Reuveny A, Borodovsky N, Tahor M, Bonkowsky JL, Chen A, Levkowitz G.
Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress. Neuron 73:279-291. [28]
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2011
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Sztainberg Y, Kuperman Y, Justice N, Chen A.
An anxiolytic role for CRF receptor type 1 in the globus pallidus. J Neurosci. 31:17416-17424. [21]
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Gene X Stress Interaction: Epigenetic Mechanisms
Stress Linked Psychopathologies
Haramati H, Navon I, Issler O, Ezra-Nevo G, Gil1 S, Zwang R Hornstein E, Chen A.
microRNA as repressors of stress induced anxiety: the case of amygdalar miR-34. J Neurosci. 31:14191-14203. [95]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Regev L, Neufeld A, Tsoory M, Kuperman Y, Getselter D, Chen A.
Prolonged and site-specific over-expression of corticotropin releasing factor reveals differential role for extended amygdala nuclei in emotional regulation. Mol. Psychiatry 6:714-728.
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Metabolism and Eating Disorders
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Jamieson PM, Cleasby ME, Kuperman Y, Morton NM, Kelly PAT, Brownstein DG, Mustard KJ, Vaughan JM, Carter RN, Hahn CN, Hardie DG, Seckl JR, Chen A, Vale WW.
Urocortin 3 transgenic mice exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high fat diet. Diabetologia 54:2392-2403. [13]
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Metabolism and Eating Disorders
Rousso-Noori L, Knobler H, Levy-Apter E, Kuperman Y, Neufeld-Cohen A, Keshet Y, Akepati VR, Klinghoffer RA, Chen A, Elson A.
Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab. 13:562-572. [24]
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Metabolism and Eating Disorders
Stress Circuitry and Regulation
Kuperman Y, Issler O, Vaughan J, Bilezikjian L, Vale W, Chen A.
Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle. Mol Endocrinol. 25:157-169. [10]
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2010
Gene X Stress Interaction: Epigenetic Mechanisms
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A.
Resilience to social stress coincides with functional DNA methylation of the CRF gene in adult mice. Nat Neurosci. 13:1351-1353. [201]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Neufeld-Cohen A, Tsoory M, Evans AK, Getselter D, Gil S, Lowry CA, Vale W, Chen A.
A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery. Proc Natl Acad Sci USA 107:19020-19025. [51]
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Complex Behavior
Stress Linked Psychopathologies
Sztainberg Y and Chen A.
An environmental enrichment model for mice. Nat Protoc. 5:1535-1539. [44]
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Gene X Stress Interaction: Epigenetic Mechanisms
Haramati S, Chapnik E, Sztainberg H, Eilam-Altstadter R, Zwang R, Gershoni N, McGlinn E, Heiser PW, Wills AM, Wirguin I, Rubin L, Misawa H, Tabin CJ, Brown R, Chen A, Hornstein E.
miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci USA 107:13111-13116. [151]
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Metabolism and Eating Disorders
Stress Circuitry and Regulation
Stress Linked Psychopathologies
Kuperman Y, Issler O, Regev L, Musseri I, Navon I, Neufeld-Cohen A, Gil S, Chen A.
Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis. Proc Natl Acad Sci USA 107:8393-8398. [36]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Neufeld-Cohen A, Evans A, Getselter G, Spyroglou A, Hill A, Gil S, Beuschlein F, Lowry C, Vale W, Chen A.
Urocortin1 and 2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits. Mol. Psychiatry 15:426-441. [44]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Regev L, Ezrielev E, Gershon E, Gil S, Chen A.
Genetic approach for intracerebroventricular delivery. Proc Natl Acad Sci USA 107:4424-4429. [22]
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Stress Circuitry and Regulation
Stress Linked Psychopathologies
Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A.
The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1. Mol. Psychiatry 15:905-917. [89]
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Weizmann Institute Branch
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